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Celiac Patients Benefit from B-Vitamin Supplement
James Meschino DC, MS, ROHP
Celiac disease is an inherited condition involving the small intestine, which is triggered by gluten contained in cereal grains. Celiac disease affects nearly 1% of the population. The pathophysiology of the disease is defined by thereaction of the gut’s immune system to the presence of gluten, which results in damage to the inner lining of the small intestine. Damage to the intestinal lining reduces the ability for celiac patients to absorb various nutrients including, iron, folate, calcium, Vitamin D, protein, fat and other food compounds. The most culpable gluten-containing grains that trigger celiac problems include the different species of wheat (e.g., durum, spelt, kamut), barley, rye, and their cross-bred hybrids (e.g., triticale, which is a cross between wheat and rye) (1).
Signs, Symptoms and Associated Conditions
Although the severity of symptoms vary considerably from one celiac patient to the next, the most common symptoms of celiac disease include weight loss, fatigue, chronic diarrhea, cramps and bloating, irritability and anemia.Weight loss is most common, but symptoms of weight gain and constipation can also occur. Some patients experience no G-I symptoms at all, only weight loss and/or fatigue. Other associated symptoms can include mouth ulcers, bone pain and dermatitis herpetiformis, which manifests as an itchy rash with bumps and blisters. This condition is linked to gluten sensitivity, and skin biopsy is required to confirm diagnosis. Some common co-morbidity issues seen in celiac patients include type 1 diabetes, Down syndrome, thyroiditis, arthritis, ataxia, depression, and neuropathy (1).
Although small bowel biopsy is usually required to confirm the diagnosis, a simple blood test is now available to detect the presence of celiac disease. As there is often a family link to the disease, family members of celiac patients should undergo this blood test to see if they have a low-grade or symptom-free version of a celiac condition (1).
Hidden Gluten in Common Foods and Dietary Management
It is the gluten in flour that helps bread and other baked goods bind and prevent crumbling. This application has made gluten an attractive addition to many processed and packaged foods. As such, celiac patients need to read the labels of all packaged and processed foods to ensure they are gluten-free. This is especially true for soups, luncheon meats and sausages. This is important as the only meaningful treatment for celiac disease is to maintain a strict gluten-free diet for life.If celiac disease is diagnosed early and treated with a gluten-free diet, the damaged tissues can heal and the risk of developing many of the long-term complications of this disease, including osteoporosis, lymphoma, and infertility can be reduced (1).
Landmark Studies Shows Importance of B-Vitamin Supplementation in Celiac Management
A 2009 study published in the World Journal of Gastroenterology showed that celiac disease patients commonly have sub-optimal nutritional status of certain B-vitamins (folic acid, vitamin B6, vitamin B12). As these vitamins are required to keep homocysteine in a safe range, many celiac patients have high blood levels of homocysteine, which increases their risk for heart disease, stroke and other vascular complications (2). Homocysteine is a chemical made in all body cellswhich, if left unchecked,diffuses into the bloodstream and causes damage to the blood vessel wall – setting the stage for plaque development with resulting increased risk for heart attack, stroke and other vascular problems. Some reports suggest that at least10% of all heart attacks in the U.S. each year are attributable to high homocysteine levels (3, 4).
The body relies on vitamin B6, folic acid and vitamin B12 to recycle homocysteine back to methionine or to serine within our cells. This keeps homocysteine blood levels in the ideal range. Thus, even marginal deficiencies in these B-vitamins can result in higher homocysteine levels, with resulting increased risk of vascular disease (3, 4).
Celiac patients have damage to the absorptive lining of the intestinal tract and, thus, do not absorb many nutrients, including B-vitamins, as well as patients with normal intestinal health. In the 2009 study, researchers gave a sub-group of celiac disease patients a B-vitamin supplement (including vitamin B6, folic acid, vitamin B12), only to discover that their blood homocysteine levels declined into the normal and safer range.As celiac patients are known to be prone to high homocysteine levels they should pay heed to the findings of this study from the standpoint of helping to reduce risk of heart attack and stroke, as an important factor in the long term management of their health (1).
In my view, this study emphasizes the need for celiac patients to take a high potency multiple vitamin and mineral that includes a B-50 complex. A supplement of this nature would also help to improve their nutritional status of all important micronutrients (vitamins and minerals), and reduce risk of premature vascular disease by helping to keep homocysteine within the desired range (under 6.3 micromoles per liter).
- Hadithi et al. Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease.World Journal of Gastroenterology, 2009; 15 (8): 955
- Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA 1995;274:1049-57.
- Kang SS, Wong PW, Malinow MR. Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease. Ann Rev Nutr 1992;12:279-98.