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NMU 45 – Mercury Consumption from Fish and Risk of ALS (Lou Gehrig’s Disease)

Nutrition / Natural Medicine Update No. 45 (March 8, 2017)

with Dr. James Meschino


Research Topic: Mercury Consumption from Fish and Risk of ALS (Lou Gehrig’s Disease)

Source: Nutra Ingredients Newsletter (February 22, 2017): Article by Hank Schultz


At the April, 2017 meeting of the American Academy of Neurology, a research paper will be presented that suggests a link between the intake of certain types of fish, their mercury content, and the increased risk for Lou Gehrig’s disease (ALS). The study included 294 individuals with ALS and 224 individuals without ALS. Researchers estimated mercury exposure of the two groups by referring to tables of mercury content of various fish, and by evaluating mercury levels in subjects’ toenails: a reliable marker of long-term mercury ingestion. The study showed that those in the top 25% for estimated annual mercury intake were at double the risk for ALS, compared to those in the lower levels.

In ALS, the motor neurons that control muscle function deteriorate, leading to progressive muscle weakness and paralysis throughout the body. Most people only live 2-5 years after the onset of the disease. Scientists are slowly making progress as to what causes this disease, but toxic substance accumulation has been identified as one of the factors associated with it. When it comes to mercury exposure from fish and seafood, which are the main dietary sources that tend to affect us, there are a few key things to know:

1. Thousands of tons of mercury are released into the air each year through pollution and waste. Bacteria and natural processes can transform mercury into the organic mercury compound methylmercury (MeHg), which is a poisonous substance. Methylmercury can accumulate in streams and oceans. Unfortunately, this toxin is in the fish we eat.  It also accumulates in the food chain, as each fish absorbs all the mercury of the smaller fish or organisms it has eaten. That is why the oldest and largest fish, such as shark or swordfish, have the highest levels of methylmercury.

2. In March, 2004, the Food and Drug Administration (FDA) and the Environmental Protection Agency (EPA) issued a joint Consumer Advisory, warning about methylmercury in fish. The advisory was intended for women who might become pregnant, are pregnant or nursing, and children, but I think we should all pay heed to the following recommendations:

  • Avoid eating shark, swordfish, king mackerel, and tilefish (also known as golden bass or golden snapper)
  • Limit consumption of all other types of fish to 12 ounces per week.
  • Limit the consumption of canned albacore (“white”) tuna or fresh tuna to no more than 6 ounces per week.
  • Limit the fish eaten by young children to even smaller portions per week.
  • Check local advisories about the safety of fish caught in local lakes, rivers, and coastal areas. If no advice is available, eat no more than 6 ounces per week of locally caught fish, and do not consume any other fish during that week.
  • If more than the recommended amount of fish is eaten in one week, eat less in the following weeks.

There was a 2017 update provided by the EPA and FDA, which also included a chart to simplify the list of Best Fish Choices, Good Fish Choices, and Fish to Avoid. I have included a link to this chart in the text below. As a quick and easy reference, I have also included a list of fish to be avoided and the ones that are safer to consume in the text below. In general, having two, maybe 3 servings of safer fish each week, is one way to get higher amounts of desirable omega-3 fats. Because we need to limit our fish intake to this degree due to the risk of mercury accumulation, many experts suggest that we also take an omega-3 fat supplement each day that includes fish and/or flaxseed oil, to help optimize important omega-3 fat status in the body. Omega-3 fat supplements are virtually devoid of any mercury or other contaminants, making them a safe option to boost omega-3 fat nutritional status.

As you probably know, omega-3 fats are quite important in cardiovascular health, in suppressing inflammation, in possibly reducing cancer risk, and certainly for brain health and the prevention of Alzheimer’s disease. So, it’s good to have an omega-3 fat strategy, just not one that also comes with the price of mercury accumulation in your body. The latest study suggests a link to Lou Gehrig’s disease, but mercury is toxic to the nervous system in general.

Check out the list of safe and unsafe fish in the text below, along with scientific references that I have also included.


Live well, eat smart, look great!

Dr. Meschino


Fish High In Mercury to Avoid:

King Mackerel
Tilefish (a.k.a. golden bass, golden snapper)

Lower in mercury but still to be avoided:
Tuna steak (also used in sushi and sashimi)
Canned Albacore white tuna

Fish to be eaten in limited quantities by women who are/may be pregnant or nursing, and young children:

Canned light tuna
Sea bass
Gulf Coast oysters
Eastern Oyster
Channel catfish (wild)
Largemouth bass
Blue mussel
Gulf Coast blue crab
Great Lakes salmon
Lake whitefish
White croaker

Fish lowest in methylmercury:

Catfish (farmed)
King crab
Fish sticks
Flounder (summer)
Trout (farmed)
Salmon (wild Pacific)



2. Best and Worst Fish and Seafood Choices Chart, 2017, Update

3. 2017, Update:

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